• Leveraging EZ Cap™ Human PTEN mRNA (ψUTP) for Advanced PI...

  2025-09-23

  Explore how EZ Cap™ Human PTEN mRNA (ψUTP) enables rigorous mechanistic studies and translational research on PI3K/Akt signaling inhibition, with emphasis on pseudouridine-mediated mRNA stability and immune evasion. This article provides technical guidance and novel perspectives for researchers utilizing in vitro transcribed mRNA in cancer research.

• 5-Ethynyl-2'-deoxyuridine (5-EdU) in Stem Cell DNA Synthe...

  2025-09-22

  Explore the advanced applications of 5-Ethynyl-2'-deoxyuridine (5-EdU) in cell proliferation assays and DNA synthesis labeling. This article provides a rigorous overview of 5-EdU’s role in stem cell research, with emphasis on click chemistry cell proliferation detection and its unique advantages for S phase DNA synthesis detection.

• Angiotensin II: Experimental Insights into AAA Models and...

  2025-09-19

  Explore the scientific applications of Angiotensin II in abdominal aortic aneurysm (AAA) models, emphasizing its role as a potent vasopressor and GPCR agonist in vascular injury and cellular senescence research. Discover novel connections between angiotensin receptor signaling pathways and emerging biomarkers in AAA.

• Mechanistic Advances with EZ Cap™ EGFP mRNA (5-moUTP) in ...

  2025-09-18

  Explore the mechanistic innovations of EZ Cap™ EGFP mRNA (5-moUTP) in enhancing mRNA stability, translation efficiency, and suppressing RNA-mediated innate immune activation. This article provides a detailed, evidence-based perspective for researchers utilizing enhanced green fluorescent protein mRNA in advanced gene expression studies.

• The results of cell culture models were further supported

  2025-03-03

  

  The results of cell culture models were further supported by in vivo studies in mice treated with PXR and/or AhR agonists, PCN and β-NF. In these mice, AhR-regulated cyp1a1, and cyp1a2 were suppressed by PXR activation as determined by real time Q-PCR (Fig. 3). The level of PXR mRNA was not changed

• Interestingly our transgenic mouse model with

  2025-03-03

  

  Interestingly, our transgenic mouse model with macrophages expressing AdipoR1 showed not only improved insulin sensitivity and inflammation in skeletal muscle and adipose tissues, but fat mass, macrophage and plasma lipid accumulation and foam cell formation was also favorably reduced resulting from

• br Acknowledgments This work was supported by Grant in aid

  2025-03-03

  

  Acknowledgments This work was supported by Grant-in-aid for Scientific Research (S) (20229008) (to T.K.), Targeted Proteins Research Program (to T.K.), the Global COE Research Program (to T.K.) and Translational Systems Biology and Medicine Initiative (to T.K.) from the Ministry of Education, Cul

• Regarding A Rs and A ARs basal

  2025-03-03

  

  Regarding A1Rs and A2ARs, basal conditions generate a low tone of endogenous adenosine and cause A1R activation, in contrast to situations of increased adenosine where A2AR activation becomes dominant. When adenosine concentrations rise, e.g. during hypoxia, also time appears likely important in reg

• plant-derived flavonoid AMPK modulates changes in lipid meta

  2025-03-03

  

  AMPK modulates changes in lipid metabolism via the regulation of fatty plant-derived flavonoid oxidation and cholesterol synthesis in the liver. The key enzymes involved include ACC and HMGCR [27,28]. Both participate in the rate-limiting steps of fatty acids and cholesterol synthesis and are inacti

• The difference in the mean values of serum ADA in

  2025-03-03

  

  The difference in the mean values of serum ADA in sputum positive PTB and controls was found to be highly significant (P levels were measured at the start of treatment and again after completion of IP in PTB patients. The fall in the levels of serum ADA was found to be statistically significant in b

• Patients with ADA SCID may experience autoimmune AEs after

  2025-03-03

  

  Patients with ADA-SCID may experience autoimmune AEs after SCT (and/or during ERT) that are thought to be related to immune dysregulation prior to achieving complete immune reconstitution. The more common autoimmune manifestations include hemolytic anemia, hypothyroidism, and immune thrombocytopenia

• Both subcutaneous s c and mucosal administration of s

  2025-03-03

  

  Both subcutaneous (s.c.) and mucosal administration of short synthetic peptide derivatives of AChR prevent the onset of EAMG, but do not treat ongoing EAMG [80], [81], [82], [83], [84], [85]. The selection of peptides for treatment is mainly based on the identification of immunodominant T- and B-cel

• Through activation of the CD GOPC pathway attenuated vaccina

  2025-03-03

  

  Through activation of the CD46–GOPC pathway, attenuated/vaccinal MeVs rapidly induce a transient phase of autophagy which then diminishes with no signs of negative regulation and precedes a second autophagy phase related to viral protein synthesis [115]. In sharp contrast, virulent MeVs do not inter

• orexins Herbal medicines have been used to treat various typ

  2025-03-01

  

  Herbal medicines have been used to treat various types of diseases and disorders for thousands of years worldwide (Li and Brown, 2009). Natural products have been the remedy of cancer chemotherapy for the past several decades. Anisomeles indica (L.) Kuntze. (Labiatae), commonly known as 'yu-chen-tsa

• br Materials and methods br

  2025-03-01

  

  Materials and methods Results and discussion During recent years, recombinant ASK1 has been obtained by expensive baculovirus-insect cell G-36 systems [20], [27]. In the present study, we constructed recombinant ASK1 and expressed in active form at high level in E. coli. Human ASK1 catalytic

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