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In KSTD the FAD adopts an extended conformation with an
2020-08-05
In Δ1-KSTD1, the FAD adopts an extended conformation with an almost planar isoalloxazine ring system, similar to what has been found in proteins belonging to the glutathione reductase family [125]. It fits in an elongated cavity in the FAD-binding domain. Its adenine end is in front of the parallel
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CRT0044876 EMT allows polarized epithelial cells to convert
2020-08-05
EMT allows polarized epithelial CRT0044876 to convert into motile mesenchymal cells through the loss of cell adhesion, which is associated with the downregulation of E-cadherin (Greenburg and Hay, 1982, Thiery, 2002). Apart from its role in normal development, EMT can be utilized by cancer cells to
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br Acknowledgements This work was supported
2020-08-05
Acknowledgements This work was supported by the major program for science and technology of Zhejiang province (grant numbers 2018C02007 and 2016C02052-9), the project of science and technology department of Zhejiang province (grant numbers 2016C32010), and the key project for science and technolo
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Chemokines are involved not only in the
2020-08-05
Chemokines are involved not only in the migration of neutrophils but also their prolonged accumulation at the site of inflammation. Chemokine receptors that play a pivotal role in the process of neutrophil accumulation (holding) are not very well defined. Stimulation of neutrophils with LPS and TNF-
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br Acknowledgements br Introduction Nonmelanoma skin cancer
2020-08-05
Acknowledgements Introduction Nonmelanoma skin cancer (NMSC) is the most common cancer in fair skinned populations. Exposure to UV radiation, along with fair skin, immune status and HPV infection, are the greatest risk factors (Akgul et al., 2006a, Feltkamp et al., 2008). A link between HPV in
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In conclusion our results show that the interaction between
2020-08-05
In conclusion, our results show that the interaction between the level of hearing loss and the COMT Val158Met polymorphism can increase the susceptibility to the clinical manifestation of tinnitus. We demonstrated that the PHC becomes involved in tinnitus in patients with hearing loss that are Met c
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Prolyl hydroxylation is a widely observed
2020-08-05
Prolyl hydroxylation is a widely observed post translational modification in collagen, an abundant animal protein. The high content (~13% per chain of the triple helical structure) of 4-hydroxyproline (Hyp,O) in collagen, togather with the natural abundance of collagen has led to the estimation that
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Previous studies demonstrated that cysteinyl LTs can trigger
2020-08-04
Previous studies demonstrated that cysteinyl-LTs can trigger several functional responses in ECs, such as endothelium-dependent relaxation of human saphenous vein [16] or human pulmonary vein [17], increased secretion of von Willebrand factor [18] and PAF accumulation leading to neutrophil adhesion
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To extend these toxicity minimization strategies to
2020-08-04
To extend these toxicity minimization strategies to 3D tissues, a more complicated mass transfer model is necessary to account sars-cov in the interstitial space, as well as transport across cell membranes. Until recently, tissue mass transport in cryobiology was modeled using classic spatially dep
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One of the mechanisms contributing to morphine
2020-08-04
One of the mechanisms contributing to morphine tolerance is uncoupling of G-protein occurs from opioid receptors, resulting in a lower analgesic response. Our previous findings in morphine tolerant neonatal rats indicate that G-protein stimulation in the brain was significantly attenuated during tol
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br Long lasting agonism Conditions of dynamic
2020-08-04
Long-lasting agonism Conditions of dynamic equilibrium govern most classical and modern theories of molecular pharmacology [44]. These conditions do not easily apply to ETA in view of the slow dissociation of the agonist–receptor complex 4, 31, 45, 46. Hence, reported affinity measures (e.g. the
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Upon further evaluation of the phage obtained from phage dis
2020-08-04
Upon further evaluation of the phage obtained from phage display, we compared the capture of each of the 4th round phage to a phage possessing the wild-type arylsulfatase A sequence (LCTPSR) using ELISA. Each phage was equivalently exposed to FGE and to the beads for capture; however, we found that
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PTEN resides at the q locus and encodes
2020-08-04
PTEN resides at the 10q23 locus and encodes a 403 amino Medroxyprogesterone (aa) protein with an N-terminal phosphatase domain (Li et al., 1997, Steck et al., 1997). The primary substrate of PTEN phosphatase is phosphatidylinositol-3,4,5-triphosphate (PIP3), a critical messenger for activation of t
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This trial has several limitations First the sample size
2020-08-04
This trial has several limitations. First, the sample size is small for the genetic association studies, and larger replications of this preliminary study are needed. Second, the genetic associations reflect a modest reduction in cocaine use to a mean proportion of .56 cocaine-positive urines. Howev
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In this context we initiated a program to develop
2020-08-04
In this context, we initiated a program to develop new antiviral chemotypes towards a host factor implicated in Methicillin sodium salt replication: the host (human) dihydrofolate reductase (DHFR) [21]. We recently identified this enzyme as the molecular target of 1-aryl-4,6-diamino-1,2-dihydrotria
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