• br Conflict of interests br

  2021-06-09

  

  Conflict of interests Introduction Ubiquitylation is a post-translational modification which impacts almost every biological process in the cell. Dysregulation of the ubiquitylation pathway is associated with several diseases, including cancer, neurodegenerative disorders, and immunological dy

• The best characterized APC C

  2021-06-09

  

  The best-characterized APC/C substrates are recruited via various linear motifs (e.g., D boxes, KEN boxes, and ABBA motifs) that serve as degrons, binding to distinct regions of the β-propeller domain of a coactivator (Figure 1, Figure 3B) (reviewed in [44]). In addition, D boxes also simultaneously

• Importantly piPolB holds a great

  2021-06-09

  

  Importantly, piPolB holds a great promise for developing novel biotechnological applications. For instance, in vitro activities of piPolB, namely, strand displacement and faithful, processive DNA polymerization, can be harnessed for efficient primer-independent whole-genome amplification, whereas th

• br Conflict of interest br Acknowledgements This work was fu

  2021-06-09

  

  Conflict of interest Acknowledgements This work was funded by the National Science Centre, Poland, grant number N N303 571539. We are greatly indebted to Patrick Fox for help with the final manuscript. Introduction Alkylating agents which interact directly with DNA to form covalent bonds h

• While the mechanism of DHODH inhibition induced differentiat

  2021-06-09

  

  While the mechanism of DHODH inhibition-induced differentiation is not fully understood, this phenomenon may be caused by pyrimidine depletion. Pyrazofurin, an inhibitor of OMP decarboxylase, was able to induce differentiation and suggests pyrimidine depletion as a potential mechanism (Sykes et al.,

• br Future directions The proposed membrane topology model of

  2021-06-09

  

  Future directions The proposed membrane topology model of DGAT1 has only three TMDs, with the N-terminus oriented toward the cytosol and the C-terminus in the ER lumen. The catalytic activity is exclusively on the luminal side of the ER membrane. The second and third TM domains are only about 10

• We aim to apply the same

  2021-06-09

  

  We aim to apply the same technology to target other collagen-binding proteins using motifs from collagens that are specific for other receptors or matrix components. Previously, we synthesized THP libraries, called Toolkits, composed of an active guest sequence flanked by five GPP host triplets that

• Our data indicate that the ability of these promiscuous kina

  2021-06-09

  

  Our data indicate that the ability of these promiscuous kinases to bind chemically diverse inhibitors is defined by the hydrophobic pocket formed by the activation loop, which is only accessible in the DFG-Asp-out conformation. Inhibitors do not artificially induce the DFG-Asp-out conformation as wa

• In vitro work by us

  2021-06-09

  

  In vitro work by us and others revealed that high affinity interaction with collagen requires dimerization and/or pre-oligomerization of DDR1 (Agarwal et al., 2007, Abdulhussein et al., 2008, Leitinger, 2003). It has also been reported that a significant percentage of the DDR1 population forms ligan

• br Materials and methods br

  2021-06-09

  

  Materials and methods Results and discussion Conclusions Clitocypin is another member of the mycocypin family of cysteine protease inhibitors that is unique to myosin inhibitor shown to exhibit strong insecticidal activity against Colorado potato beetle larvae. This effect is concentration

• SRT1720 br NF B and STAT as Regulators of the CDK

  2021-06-09

  

  NF-κB and STAT as Regulators of the CDK System While current data support the concept that CDKs augment the proinflammatory activity of NF-κB, our understanding of the function of this transcription factor system in CDK regulation remains patchy. Seminal studies showed the contribution of NF-κB t

• br Results br Discussion GPCRs recognize a

  2021-06-09

  

  Results Discussion GPCRs recognize a broad range of molecules with a vast chemical mitomycin through different mechanisms. Our understanding of the recognition of lipid mediators by GPCRs primarily comes from the structural studies of receptors for lysophospholipids and endocannabinoids inclu

• In a previous study we reported that the systemic administra

  2021-06-09

  

  In a previous study we reported that the systemic administration of the α1-adrenergic receptor antagonist prazosin attenuates the deficit in TAE226 reward function associated with precipitated nicotine withdrawal (Bruijnzeel et al., 2010). One of the aims of the present experiments was to investigat

• In the last and the most challenging part three mixtures

  2021-06-09

  

  In the last and the most challenging part, three mixtures were selected to evaluate the reliability of the presented correlation and the CPA model. For Athabasca bitumen, Amani et al. [25] measured the experimental data at very high temperatures compared to the thermal recovery range up to 644 K (ne

• Table shows all AP courses taken by

  2021-06-09

  

  Table 5 shows all AP courses taken by participants, in descending order with respect to percentage of higher-order keywords. Table 5 also includes t-tests of mean differences for average CPA exam scores of participants who have taken (vs. not taken) AP courses (AP_ENGAGE), and average CPA exam score

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