• It has been reported that aberrant GPR expressions were

  2021-10-28

  

  It has been reported that aberrant GPR120 expressions were detected in colorectal carcinomas, compared with normal tissues. In addition, GPR120 stimulated cell motile activity and angiogenic property in colon cancer cells [10]. Recently, we indicated that GPR40 suppressed cell motile and invasive ac

• From a cell signaling perspective given the importance of ag

  2021-10-28

  

  From a cell signaling perspective, given the importance of agonist-directed signaling and biased agonism, one goal of this research update was to review the known contributions of G protein-dependent versus β-arrestin-dependent signals toward promotion of beneficial functions that FFA4 facilitates.

• We have presented evidence that only

  2021-10-28

  

  We have presented evidence that only muscle FBPase is detectable within HL-1 cells. This is consistent with past findings of the Eschrich's group, which showed that in rat heart 16,16-Dimethyl Prostaglandin E2 expression of FBPase is almost exclusively limited to the muscle isozyme [3]. Results of

• Defining the cooperation between molecular pathways within h

  2021-10-28

  

  Defining the cooperation between molecular pathways within highly complex biological systems, such as those between immune cell networks and target tissues is certainly a hard task. Recently, there are many investigations in the pathogenesis of renal graft rejection, one of the most evident investig

• In addition to the regulation afforded by

  2021-10-28

  

  In addition to the regulation afforded by calcineurin/NFAT axis, it has been shown that deregulation of some microRNAs (e.g. miR-155) can induce activation of Fas/FasL-in various cell types [72]. Furthermore, Fas–FasL interactions appear to be an important mechanism for the maintenance of immune pri

• We characterized the enzyme corresponding to N FPP was

  2021-10-28

  

  We characterized the enzyme corresponding to N1. FPP was the most effective substrate as allylic diphosphate, and the activities with GPP and DMAPP were 50% and 11% that with FPP, respectively. The analysis of the prenols resulting from the treatment of prenyl diphosphates with STF 31 phosphatase (

• Our observation of LPS induced increase

  2021-10-28

  

  Our observation of LPS-induced increase in the sensitivity of cultured endothelium-intact coronary (+)-Aphidicolin towards stimulation with selective ETB receptor agonist (S6c) could be explained by activation of TLRs receptors located on the endothelium of rat coronary arteries. However, the possi

• Introduction Post translational modifications to the

  2021-10-28

  

  Introduction Post-translational modifications to the N-terminal tails of the histone proteins play crucial roles in genome regulation [1]. These modifications (e.g. acetylation, methylation, phosphorylation) are deposited by so-called ‘writer’ enzymes and dynamically removed by the action of ‘erase

• GPR A a G protein coupled

  2021-10-27

  

  GPR109A, a G-protein-coupled receptor located mainly on adipocyte cell membranes, has been identified as the molecular target for nicotinic dilutions [[5], [6], [7]] and mediator of NEFA reduction [5]. As a mechanism of NEFA-lowering, it is recognized that activation of GPR109A leads to Gi-mediated

• L Family Leguminosae widely distributed in

  2021-10-27

  

  L. (Family Leguminosae) widely distributed in tropical and subtropical regions of the world. As a medicinal and edible plant, it is widely used in Asia, especially in China, Korea, Japan and India. It was first recorded in Shen Nong Ben Cao Jing (神农本草经), and was described having the effect of clear

• Notch signaling maintains the balance between neural

  2021-10-27

  

  Notch signaling maintains the balance between neural stem cells and neural progenitors (Aguirre et al., 2010, Basak and Taylor, 2007, Mizutani et al., 2007). Conditional knock out of Notch causes depletion in the progenitor pool, showing that Notch is required for the maintenance of neural stem cell

• Since our new compound Fex could be

  2021-10-27

  

  Since our new compound Fex-3 could be a new FXR ligand, we try to demonstrate that Fex-3 was an intestinal-restricted FXR agonist which only activated FXR in the intestine not in the liver or other organs. Initially, we investigated this in Caco-2 Lck Inhibitor with transwell experiments. From and

• bcl-2 family br Methods and materials br Conflict of

  2021-10-27

  

  Methods and materials Conflict of interest statement Introduction Ferroptosis (ferro = “ferrous ion (Fe2+)”, ptosis = “fall”), implicating the crucial role of cellular iron played in cell death, is a new form of nonapoptotic programmed cell death characterized by iron-dependent accumulation

• Introduction Post translational modifications to the N termi

  2021-10-27

  

  Introduction Post-translational modifications to the N-terminal tails of the histone proteins play crucial roles in genome regulation [1]. These modifications (e.g. acetylation, methylation, phosphorylation) are deposited by so-called ‘writer’ enzymes and dynamically removed by the action of ‘erase

• br Substrate Interactions Outside of the

  2021-10-26

  

  Substrate Interactions Outside of the Catalytic Cleft As for other types of protein–protein interactions, kinase–substrate docking interactions can occur through large binding interfaces or through recognition of short linear sequence motifs. For kinases with a large number of substrates, the use

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