• The activation of GPR FFA signaling

  2022-07-29

  

  The activation of GPR40/FFA1 signaling triggers the PLC/PIP2 signaling pathway and results in Ca2+ release from the endoplasmic reticulum (ER). Increased Ca2+ levels may lead to activation of different protein kinases, such as Ca2+/calmodulin-dependent protein kinase type IV, Akt, extracellular sign

• Chlorprothixene We detected the FFAR protein with a molecula

  2022-07-29

  

  We detected the FFAR2 protein with a molecular mass of about 50 kDa, which is comparable to the main band detected in pigs (Li et al., 2014) but different from the calculated size based on the sequence (Wang et al., 2009). The size difference can be explained, at least in part, by glycosylation site

• Next we aimed to investigate if the cardiac

  2022-07-29

  

  Next, we aimed to investigate if the cardiac apoptosis induced by CO-HFD, LA, T1DM or hyperglycemia involves up-regulation and activation of Fas/FasL-mediated cell death and if such effects are mediated by ROS and/or Ca+2/calcineurin/NFAT signaling axis. Similar to previous reports, [8], [9], [10],

• In the FARM motifs of GGPPSs hydrophobic amino

  2022-07-29

  

  In the FARM motifs of GGPPSs, hydrophobic Fmoc-D-Lys(Boc)-OH are replaced by aliphatic amino acids, which are more flexible residues and allow the entrance of longer substrates into the pocket (Wang and Ohnuma, 2000). It has been reported that the lepidopteran Manduca sexta CA possesses GGPP syntha

• scr 11 br Materials and methods br Results br

  2022-07-29

  

  Materials and methods Results Discussion Cell migration not only plays major roles in physiological events, such as embryo implantation, embryogenesis, morphogenesis, neurogenesis, angiogenesis, wound healing and inflammation [[29], [30], [31]], but it is also implicated in the pathophysiol

• Contrary to the transient nature of signal transmission thro

  2022-07-29

  

  Contrary to the transient nature of signal transmission through PLCβ, genome-wide RNAi screens revealed that the signaling events driven by Gαq that result in aberrant cell proliferation depends on highly specific protein-protein interactions, rather than solely on diffusible second messenger system

• CTX0294885 The present study was designed to

  2022-07-29

  

  The present study was designed to clarify the distribution and the function of the endothelin receptors in the guinea-pig urinary bladder. We found that endothelin-1 produced a clear tonic contraction via both CTX0294885 subtypes, the endothelin ETA and ETB receptor, and that sarafotoxin S6c also in

• The neurotransmitter histamine plays a key role in

  2022-07-28

  

  The neurotransmitter histamine plays a key role in the sleep-wake cycle and in learning and memory. Alterations in Busulfan histamine levels are closely connected with central nervous system dysfunction, and are thought to contribute to neurological disorders, including Alzheimer's disease and depr

• In the present study fasting blood glucose and insulin level

  2022-07-28

  

  In the present study, fasting blood glucose and insulin levels were not significantly different between GA patients and control cases. Normal mammalian cells typically acquire fatty acids from the circulation owing to insulin, which is the most lipogenic hormone in the subset of adult tissues, inclu

• Here we report the genomic structure and the phylogenetic an

  2022-07-28

  

  Here we report the genomic structure and the phylogenetic analysis of testis-specific Ser/Thr kinase haspin gene. Materials and methods Results Discussion The isolation and analysis of haspin genomic DNA showed that haspin was an intron-less gene and localized in an intron of integrin αM29

• The number of small molecule GSK inhibitors is

  2022-07-27

  

  The number of small molecule GSK-3 inhibitors is continuously rising and many have been tested in animals. These studies have provided additional support for specific roles of GSK-3 in neuronal functions under both normal and pathological conditions. Inhibition of GSK-3 has profound effect on neurop

• To apply the recently developed GPR ligands

  2022-07-27

  

  To apply the recently developed GPR35 ligands to CNS disorders, it is necessary to understand whether GPR35 is expressed by any identified cell types in the 2-APB and whether activation or blockade of this receptor has any consequence on the activity of the neuronal circuitry. To this end, the pres

• GlxI is a member of the

  2022-07-27

  

  GlxI is a member of the βαβββ superfamily of proteins, consisting of fosfomycin resistance protein (FosA), methylmalonyl-CoA epimerase (MMCE), extradiol dioxygenase (DIOX), mitomycin C resistance protein (MRP) and bleomycin resistance protein (BRP) [29], [30], [31]. These proteins are believed to ha

• br MUTYH associated polyposis br MUTYH and

  2022-07-27

  

  MUTYH-associated polyposis MUTYH and its metal cofactors MUTYH harbors two vital cofactors, both of which are located remotely from the active site (Fig. 6). One of these cofactors, a [4Fe-4S]2+(Fe-S) cluster, is chelated by four Cys residues in the N-terminal domain, and positions an Fe-S clu

• Uracil DNA glycosylase UDG is

  2022-07-27

  

  Uracil-DNA glycosylase (UDG) is a highly conserved damage repair enzyme which can specifically recognize and excise uracil residue within the DNA sequences and actuate the DNA histone methyltransferase inhibitor excision repair (BER) pathway which keeps the maintenance of genomic integrity and stab

15477 records 366/1032 page Previous Next First page 上5页 366367368369370 下5页 Last page