• In the largest published case series Rossi et al identified

  2019-04-19

  

  In the largest published case series, Rossi et al. identified seven cases of infant B-ALL, including three cases of congenital leukemia, with lineage switch from B-lymphoid to myelomonocytic leukemia [12]. An additional two cases were described with a switch from AML M5 to B-ALL. Of the nine describ

• br Specific concerns of each VT substrate br Complications

  2019-04-19

  

  Specific concerns of each VT substrate Complications Potential complications associated with epicardial catheter ablation of VTs are very rare and the procedures are generally safe [4–6,11,13–16,17,25,33–35]. However, transthoracic epicardial access and ablation could result in uncommon compli

• br Methods br Results Globally CCI increased by percent poin

  2019-04-19

  

  Methods Results Globally, CCI increased by 0·82 percent points a year, from 54·8% in 1994, to 71·2% in 2014 (CCI estimates at national level, stratified by wealth quintiles and place of residence, are presented in the appendix, pp 6–15). This gain was largely driven by low-income countries, wh

• According to Weitzman classification patients had a single

  2019-04-19

  

  According to Weitzman classification [43] 15 patients had a single ONJ lesion (4A) and 9 patients had multiple lesions (4B) or a “multifocal” lesion (Table 2). Six patients interrupted the treatment with O3 gas application for disease progression (five patients) and for fear of an experimental ther

• Approximately of the patients who developed BM during their

  2019-04-19

  

  Approximately 50% of the patients who developed BM during their palliative disease course received BM-related radiotherapy and/or surgery; 12% of the patients received both therapy options. Our data confirms that the majority of patients with BM will respond to a low course of radiotherapy with good

• br Conclusion br Conflict of interest This work was supporte

  2019-04-19

  

  Conclusion Conflict of interest This work was supported by Medtronic Japan. MN received honoraria from Medtronic Japan, St. Jude Medical Japan and Boston Scientific Japan. YE and TI received honoraria from Medtronic Japan. HS received honoraria from Japan Lifeline. YA, TT, and KK are employees

• br Discussion The major finding in this case

  2019-04-19

  

  Discussion The major finding in this case is that implantation of an active-fixation atrial pacing lead in the right atrial appendage caused right coronary artery perforation, resulting in life-threatening tamponade. Myocardial perforation with or without cardiac tamponade has been reported as a

• Despite our best efforts the cause of

  2019-04-19

  

  Despite our best efforts, the cause of SCD in young individuals is sometimes not established; no cause is identified in up to 40% of cases. Importantly, whether a cause of death is established or not, the possibility of an underlying inherited cardiac disorder remains in many cases, including the p

• Case reports br Discussion RV perforation is a rare but

  2019-04-19

  

  Case reports Discussion RV perforation is a rare but serious complication of PPM and ICD implantation. It is diagnosed when at least the tip of a passive fixation lead or the screw of an active fixation lead passes through the myocardium and extends into the pericardial cavity [1]. This complica

• The mean follow up period was months ICD discharges and

  2019-04-19

  

  The mean follow-up period was 12 months. ICD discharges and ventricular tachycardia (VT) events were recorded by reviewing Holter, exercise ECG tracings, ICD interrogation reports, and clinic visit notes. Sustained VT was considered as VT with a rate of >100 beats per minute and duration of >30s or

• In humans the two primary bile acids CA and CDCA

  2019-04-19

  

  In humans, the two primary bile acids CA and CDCA make up approximately 70%–80% of the total bile no precursors pool. DCA is the major secondary bile acid, which may account for approximately 20% of the total bile acid pool. Among all bile acid species, the secondary bile acid LCA is highly toxic.

• We built and improved on previous models of research

  2019-04-19

  

  We built and improved on previous models of research capacity strengthening and used an integrated approach not only focused on individual researchers or providing technical assistance but also on fostering an institutional environment that ezh2 inhibitor is supportive of safe and ethical science.

• Stigma and discrimination experienced by

  2019-04-19

  

  Stigma and discrimination experienced by sex workers, injection drug users, and men who have sex with men is tough to tackle. Responses need to be tailored to very different circumstances and require interventions on several levels: policy, societal, health system, and individual. There is no magic

• AICAR As Becerra Posada writes attention must

  2019-04-19

  

  As Becerra-Posada writes, attention must be given to the development of capacities and structures for taking health into account in all policies. But should the public health AICAR also give attention to raising the standing of health on the political agenda and to helping induce political solution

• Desde mediados de la d cada de

  2019-04-18

  

  Desde mediados de la década de los sesenta, la embajada argentina pedía informes sobre las actividades políticas en general y sobre las consideradas subversivas en Guatemala. A juicio de la embajada, en 1978 no se podía analizar la “ola de violencia” en Guatemala sin incluirla en el contexto de lo q

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